Methodology

What "evidence-graded"
actually means here.

Every recommendation in the stack check and every guide on this site carries one of three grades. Here is exactly how they're assigned — so you can disagree with us intelligently.

Open book with a supplement bottle and magnifying glass
Strong

Replicated human evidence

Multiple randomized controlled trials or meta-analyses in humans, with consistent direction of effect. Example: vitamin D for correcting measured deficiency.

Moderate

Plausible, partially demonstrated

Mechanistic evidence plus limited or mixed human trials. Real effect likely in some contexts, oversold in marketing. Example: zinc lozenges for cold duration.

Limited

Mostly marketing

Animal or in-vitro data only, or human trials that failed to replicate. We'll say so plainly. Example: collagen for skin in well-nourished adults.

Sources we grade against

Reference values (RDA, UL) follow the NIH Office of Dietary Supplements and EFSA. Effect claims are graded against peer-reviewed trials and Cochrane reviews, prioritized by study quality — never by what sells. Retail links may earn a commission, but no brand can pay for a grade, a placement, or a recommendation.

Review process

Guides are drafted against this framework, fact-checked against primary sources, and reviewed by a registered dietitian before publishing. Each guide shows its last-updated date; reference values are re-checked when source guidelines change.

Disagree with a grade? Good.

Run the stack check and see the evidence behind each card — then push back.

Check my stack